Administrative Appointment

Senior Associate Consultant II-Research, Department of Physical Medicine & Rehabilitation

Senior Associate Consultant II-Research, Department of Physiology & Biomedical Engineering

Academic Rank

Associate Professor of Physical Medicine and Rehabilitation

Assistant Professor of Biomedical Engineering

EDUCATION

Ph.D. – Rehabilitation Science

University of Minnesota, Twin Cities

MA – Kinesiology (Biomechanics track)

The University of Texas at Austin

BA – Physics

The University of Texas at Austin

Kristin D. Zhao, Ph.D., uses innovative technologies, device fabrication and imaging methods to investigate pathogenesis related to the musculoskeletal system. The long-term goal of Dr. Zhao’s research team is to develop and use diagnostic tools to enable earlier diagnosis, prescribe effective interventions for individuals with disabilities and diseases, and assess outcomes.

Dr. Zhao’s team consists of physicians, nurses, therapists, engineers and administrative staff who collaborate with external and internal investigators. Fields of study included in Dr. Zhao and her colleagues’ research include radiology, neurosurgery, orthopedics, pediatrics, physiology and biomedical engineering, and physical medicine and rehabilitation. Dr. Zhao’s research focuses on the development of assistive technologies across the lifespan, as well as the integration of novel technologies to address issues such as spinal cord injury, upper limb loss, osteoarthristis and neuromuscular diseases. Additionally Dr. Zhao’s team is interested in including analyses of sex differences and alleviating health disparities while addressing important translational questions.

Organizations including the National Institutes of Health, Paralyzed Veterans of America and Department of Defense have all contributed funding to Dr. Zhao’s research. Currently, Dr. Zhao is collaborating on research with external investigators from St. Catherine University, Vanderbilt University, Italian Institute of Technology/University of Pisa and the University of Minnesota.

Source: https://www.mayo.edu/research/faculty/zhao-kristin-d-ph-d/bio-00027470

PUBLICATIONS

Emergence of Epidural Electrical Stimulation to Facilitate Sensorimotor Network Functionality After Spinal Cord Injury.

Calvert JS, Grahn PJ, Zhao KD, Lee KH.

Neuromodulation. 2019 Apr;22(3):244-252. doi: 10.1111/ner.12938. Epub 2019 Mar 6. Review.

The effect of subscapularis muscle contraction on coaptation of anteroinferior glenohumeral ligament-labrum complex after Bankart repair.

Itoigawa Y, Hooke AW, Sperling JW, Steinmann SP, Zhao KD, Itoi E, An KN.

J Biomech. 2019 Mar 6;85:134-140. doi: 10.1016/j.jbiomech.2019.01.023. Epub 2019 Jan 22.

Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis.

Calvert JS, Grahn PJ, Strommen JA, Lavrov IA, Beck LA, Gill ML, Linde MB, Brown DA, Van Straaten MG, Veith DD, Lopez C, Sayenko DG, Gerasimenko YP, Edgerton VR, Zhao KD, Lee KH.

J Neurotrauma. 2019 May 1;36(9):1451-1460. doi: 10.1089/neu.2018.5921. Epub 2018 Dec 15.

MRI vs CT-based 2D-3D auto-registration accuracy for quantifying shoulder motion using biplane video-radiography.

Akbari-Shandiz M, Lawrence RL, Ellingson AM, Johnson CP, Zhao KD, Ludewig PM.

J Biomech. 2019 Jan 3;82:375-380. doi: 10.1016/j.jbiomech.2018.09.019. Epub 2018 Sep 29.

Publisher Correction: Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.

Gill ML, Grahn PJ, Calvert JS, Linde MB, Lavrov IA, Strommen JA, Beck LA, Sayenko DG, Van Straaten MG, Drubach DI, Veith DD, Thoreson AR, Lopez C, Gerasimenko YP, Edgerton VR, Lee KH, Zhao KD.

Nat Med. 2018 Dec;24(12):1942. doi: 10.1038/s41591-018-0248-7.

Dr. Fehlings is the Vice Chair Research for the Department of Surgery at the University of Toronto and Head of the Spinal Program at Toronto Western Hospital, University Health Network. Dr. Fehlings is a Professor of Neurosurgery at the University of Toronto, holds the Gerry and Tootsie Halbert Chair in Neural Repair and Regeneration, is a Scientist at the McEwen Centre for Regenerative Medicine and a McLaughlin Scholar in Molecular Medicine. In the fall of 2008, Dr. Fehlings was appointed the inaugural Director of the University of Toronto Neuroscience Program (which he held until June 2012) and is Co-Director of the newly formed University of Toronto Spine Program.

Dr. Fehlings combines an active clinical practice in complex spinal surgery with a translationally oriented research program focused on discovering novel treatments for the injured brain and spinal cord. This is reflected by the publication of over 800 peer-reviewed articles (h-index 86) chiefly in the area of central nervous system injury and complex spinal surgery. Dr. Fehlings leads a multi-disciplinary team of researchers that is examining the application of stem cells, nanotechnology and tissue engineering for CNS repair and regeneration. He is also Chair of the Advisory Committee of the AO Foundation Clinical Investigation Division and leads several international clinical research trials. In addition, Dr. Fehlings is involved in a number of exciting initiatives, including the Center for Advancing Neurotechnological Innovation to Application (CRANIA).

Dr. Fehlings has received numerous prestigious awards including the Gold Medal in Surgery from the Royal College of Physicians and Surgeons (1996), nomination to the Who’s Who list of the 1000 most influential scientists of the 21st century (2001), the Lister Award in Surgical Research (2006), the Leon Wiltse Award from the North American Spine Society for excellence in leadership and/or clinical research in spine care (2009), the Olivecrona Award (2009) — the top award internationally for neurosurgeons and neuroscientists awarded by the Nobel Institute at the Karolinska Institute in Stockholm for his important contributions in CNS injury repair and regeneration, the Reeve-Irvine Research Medal in Spinal Cord Injury (2012), the Golden Axon Leadership Award (2012), the Mac Keith Basic Science Lectureship Award for significant contributions to the basic science of cerebral palsy and childhood onset disabilities (2012), and was the Mayfield Lecturer (2012).

In 2012, Dr. Fehlings served as the 40th President of the Cervical Spine Research Society (CSRS) — the only Canadian to do so — and was honoured with the CSRS Presidential Medallion for outstanding leadership and contributions to cervical spine research. In 2013, Dr. Fehlings was honoured with the Queen Elizabeth II Diamond Jubilee Medal presented to him by the Honourable Stephen Harper, the H. Richard Winn Prize from the Society of Neurological Surgeons, the Jonas Salk Award for Scientific Achievements from the March of Dimes Canada and the Henry Farfan Award from the North American Spine Society. In 2014, Dr. Fehlings was elected to the Fellowship of the Royal Society of Canada and to the Canadian Academy of Health Sciences, and in 2016 won the Royal College of Physicians and Surgeons Mentor of the Year Award.

 

 

Source: http://drfehlings.ca/team/michael-g-fehlings/

 

 

 

 

Last publications related with Spinal Cord Injury

Association of pneumonia, wound infection and sepsis with clinical outcomes after acute traumaticspinal cord injury.

Jaja B, Jiang F, Badhiwala JH, Schär RT, Kurpad SN, Grossman R, Harrop JS, Guest J, Toups E, Shaffrey C, Aarabi B, Boakye M, Fehlings MG, Wilson JR.

J Neurotrauma. 2019 Apr 22. doi: 10.1089/neu.2018.6245. [Epub ahead of print]

Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury.

Vawda R, Badner A, Hong J, Mikhail M, Lakhani A, Dragas R, Xhima K, Barretto T, Librach CL, Fehlings MG.

Stem Cells Transl Med. 2019 Mar 26. doi: 10.1002/sctm.18-0192. [Epub ahead of print]

Endogenous Interleukin-10 Deficiency Exacerbates Vascular Pathology in Traumatic Cervical Spinal Cord Injury.

Badner A, Vidal PM, Hong J, Hacker J, Fehlings MG.

J Neurotrauma. 2019 Apr 24. doi: 10.1089/neu.2018.6081. [Epub ahead of print]

Generation of Definitive Neural Progenitor Cells from Human Pluripotent Stem Cells for Transplantation into Spinal Cord Injury.

Khazaei M, Ahuja CS, Rodgers CE, Chan P, Fehlings MG.

Methods Mol Biol. 2019;1919:25-41. doi: 10.1007/978-1-4939-9007-8_3.

Time is spine: a review of translational advances in spinal cord injury.

Badhiwala JH, Ahuja CS, Fehlings MG.

J Neurosurg Spine. 2018 Dec 20;30(1):1-18. doi: 10.3171/2018.9.SPINE18682. Review.

Global burden of traumatic brain and spinal cord injury.

Badhiwala JH, Wilson JR, Fehlings MG.

Lancet Neurol. 2019 Jan;18(1):24-25. doi: 10.1016/S1474-4422(18)30444-7. Epub 2018 Nov 26. No abstract available.

Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review.

Yousefifard M, Sarveazad A, Babahajian A, Baikpour M, Shokraneh F, Vaccaro AR, Harrop JS, Fehlings MG, Hosseini M, Rahimi-Movaghar V.

J Neurochem. 2019 May;149(3):317-330. doi: 10.1111/jnc.14637. Epub 2019 Jan 15. Review.

Source: https://www.ncbi.nlm.nih.gov/pubmed

My central research aim is to understand how animals learn to generate and control motor behavior in health and disease. In my lab, we study mechanisms of circuit assembly, function and plasticity that lead to motor learning and recovery after neurotrauma.

We use a wide variety of methods, including detailed motor kinematic assessments, mouse genetics, viral tracing and manipulation, electrophysiological and imaging techniques. This approach allows us to manipulate functions of specific neuronal populations, which in turn helps us to understand their role in sensorimotor circuit output and plasticity.

since 2016           NERF Principal Investigator

since 2016           Assistant professor at the Department of Neurosciences, KU Leuven

2010–2016         Postdoc fellow, Friedrich Miescher Institute for Biomedical Research,                                                       Switzerland

2010                       PhD, University of California Los Angeles, US

2003                       BS Neuroscience with High Honors, Oberlin College, Ohio, US

Key publications

• Aya Takeoka, Silvia Arber, Functional local proprioceptive feedback circuits initiate and maintain locomotor recovery after spinal cord injury, Cell Reports, April 2, 2019, 2019

• Ludwig Ruder, Aya Takeoka, Silvia Arber, Long-distance descending spinal neurons ensure quadrupedal locomotor stability, Neuron, 92(5): 1063-1078, 2016

• Emanuela Basaldella, Aya Takeoka, Sigrist Markus, Silvia Arber, Multisensory signaling shapes vestibulo-motor circuit specificity, Cell 163(2), 301-312, 2015

• Aya Takeoka, Isabel Vollenweider, Grégoire Courtine, Silvia Arber, Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury, Cell, 159(7), 1626-1639, 2014

• Aya Takeoka, Devin L Jindrich, Cintia Muñoz-Quiles, Hui Zhong, Rubia van den Brand, Daniel L Pham, Matthias D Ziegler, Almudena Ramon-Cueto, Roland R Roy, V Reggie Edgerton, Patricia E Phelps, Axon regeneration can facilitate or suppress hindlimb function after olfactory ensheathing glia transplantation, Journal of Neuroscience 31 (11) 4298-4310, 2011

I graduated from the Karolinska Institute in Stockholm in 1979 with a basic medical degree – MD and a research degree-PhD. Following a “post doc” year in Montreal I returned to the Karolinska Institute to become an Assistant Professor. After completing surgical training in Stockholm and Paris, I specialised in Nerve and Plexus surgery, I was made an Associate Professor of Surgery in 1988 and then Head of the Division of Neuro-Orthopaedics at the Karolinska Hospital. I founded a Swedish National Centre for complicated nerve injuries.

I was recruited as a Consultant Orthopaedic Nerve Surgeon to the Royal National Orthopaedic Hospital, Stanmore in London 1996. I was awarded a visiting Professorship at Imperial College of Science, Technology and Medicine in 2002 and 2003 a Professorship in Nerve Surgery from University College London. In 2006 I became a Professor of Hand Surgery at the Karolinska Institute.

I have 20 years of experience as a consultant. I am a leading and internationally renowned surgeon and basic scientist that has pioneered and developed surgical treatments of complicated nerve disorders such as brachial and lumbosacral plexus . I treat severe,complicated nerve lesions and conditions.

 

Activity

My main activities include nerve and plexus trauma, tumours as well as entrapment disorders of nerves. I also do hand surgery.

I direct a National Centre for the surgical treatment of complicated nerve injuries including nerve plexus and associated spinal cord injuries.

I have devoted the last 30 years to basic and clinical researches to solve and develop successful methods to repair spinal cord injuries associated with nerve plexus trauma.

I have produced 12 Chapters in books, 15 Review articles and 90 peer review articles in international highly rated clinical and basic science journals. I have written one book on a surgical technique that restores function after a type of spinal cord injury. I am a reviewer for several international scientific journals.

 

Publications

Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury.

Goncalves MB, Clarke E, Jarvis CI, Barret Kalindjian S, Pitcher T, Grist J, Hobbs C, Carlstedt T, Jack J, Brown JT, Mills M, Mumford P, Borthwick AD, Corcoran JPT.

Bioorg Med Chem Lett. 2019 Apr 15;29(8):995-1000. doi: 10.1016/j.bmcl.2019.02.011. Epub 2019 Feb 11.

Surgical reconstruction of spinal cord circuit provides functional return in humans.

Carlstedt T, James N, Risling M.

Neural Regen Res. 2017 Dec;12(12):1960-1963. doi: 10.4103/1673-5374.221145. Review.

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth.

Goncalves MB, Wu Y, Trigo D, Clarke E, Malmqvist T, Grist J, Hobbs C, Carlstedt TP, Corcoran JPT.

Neurobiol Dis. 2018 Mar;111:70-79. doi: 10.1016/j.nbd.2017.12.016. Epub 2017 Dec 20.

Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits.

James ND, Angéria M, Bradbury EJ, Damberg P, McMahon SB, Risling M, Carlstedt T.

Front Neurol. 2017 Jul 24;8:358. doi: 10.3389/fneur.2017.00358. eCollection 2017.

Corrigendum: New Treatments for Spinal Nerve Root Avulsion Injury.

Carlstedt T.

Front Neurol. 2017 Jul 5;8:326. doi: 10.3389/fneur.2017.00326. eCollection 2017.

Professor, Department of Physiology, Graduate School of Medicine, Keio University

Chairman, Graduate School of Medicine, Keio University

Japanese physiology professor and the current dean of Keio University School of Medicine. He is also the team leader of the Laboratory for Marmoset Neural Architecture, at RIKEN Brain Science Institute.

Neural stem cells (NSCs) possess the capability for self-renewal and are multipotent, that is, they can give rise to both neurons and glial cells. Embryonic NSCs are expected as a source for transplantation therapy, and adult NSCs as a basis of noninvasive treatment of neurological disorders. However, because the fate of embryonic NSCs is generally predetermined and restricted temporally, a given embryonic NSC cannot generate all of the cell types existing in the CNS. For example, early NSCs generate neurons but not glia; later NSCs generate both types of cells, however, they cannot give rise to early-born neurons. Meanwhile, actual use of adult NSCs for regenerative medicine is a vision far from being fulfilled because of the as-yet unexplored physiology and mechanisms of adult neurogenesis.To resolve these problems, we propose to establish in-vitro culture systems, and to develop a powerful model for investigating the mechanisms underlying early CNS development. Furthermore, we are examining adult neurogenesis both anatomically and physiologically by combining comprehensive in-vitro analyses, such as DNA microarray and ChIP-sequencing, and in-vivo analyses using knockout or knock-in mice. Findings from these approaches are expected to be applicable to regenerative therapy for neurodegenerative disorders.

PUBLICATIONS

1. Naka H, Nakamura S, Shimazaki T, Okano H. Requirement for COUP-TFI and II in the temporal specification of neural stem cells in central nervous system development. Nature Neurosci. 2008 Aug 24:11 (9): 1014-1023.
2. Kaneko S, Iwanami A, Nakamura M, Kishino A, Kikuchi K, Shibata S, Okano HJ, Ikegami T, Moriya A, Konishi O, Nakayama C, Kumagai K, Kimura T, Sato Y, Goshima Y, Taniguchi M, Ito M, He Z, Toyama Y, Okano H. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat Med. 2006 Dec;12(12):1380-9.
3. Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med. 2006 Jul;12(7):829-34.
4. Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, Okano H. Ontogeny and Multipotency of Neural Crest-Derived Stem Cells in Mouse Bone Marrow, Dorsal Root Ganglia and Whisker Pad.Cell Stem Cell 2. 2008 Apr 10:2(4):392-403.
5. Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Okano H, Alvarez-Buylla A. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science. 2006 Feb 3;311(5761):629-32.

Source: http://www.med.keio.ac.jp/gcoe-stemcell/english/member/okano.html

Michael Lane, PhD, is an Associate professor in the Department of Neurobiology & Anatomy at Drexel University College of Medicine. He leads a research team consisting of two graduate students, a postdoc  and one junior faculty member (instructor).

After completing his graduate studies and early postdoctoral work in spinal cord injury (SCI) in Australia at the University of Melbourne, Dr. Lane relocated to the University of Florida to investigate the neuroplastic potential of the injured cervical spinal cord. This research focused  on respiratory dysfunction and spontaneous neuroplastic recovery. In 2013, Dr. Lane moved to the Spinal Cord Research Center within Drexel University College of Medicine’s Department of Neurobiology & Anatomy to continue his research into neuroplasticity following cervical SCI. Employing a range of electrophysiological, behavioral and neuroanatomical methods, the present goal of his research team is to 1) better define the ontribution of spinal interneurons to functional and anatomical plasticity and 2) develop and test therapeutic strategies toharness the therapeutic potential of these interneurons and  enhance spontaneous neuroplasticity and lasting functional recovery. Among those therapeutic approaches being tested are intraspinal cell transplantation and rehabilitative strategies.

Current Funding

Title: “Neural transplants to promote respiratory plasticity after spinal cord injury”

Agency: National Institutes of Health, NINDS (R01 NS104291)

Project dates: 2018-2022

Title: “Stem cell–derived spinal interneurons to repair the injured spinal cord”

Agency: The Lisa Dean Moseley Foundation

Project dates: 2017

Title: “Repair of the Chronically Injured Spinal Cord with Cell Therapy”

Agency: Wings for Life Foundation

Project dates: 2019-2021

Recent Publications

“The neuroplastic and therapeutic potential of interneurons in the injured spinal cord”

Zholudeva LV, Qiang L, Marchenko V, Dougherty KJ, Sakiyama-Elbert SE, Lane MA

Trends in Neuroscience (invited), 41(9): 625-639 [PMID: 30017476] (2018)

“Transplantation of neural progenitors and V2a interneurons after spinal cord injury”

Zholudeva LV, Iyer N, Qiang L, Spruance VM, Randelman ML, Bezdudnaya TG, Fischer I, Sakiyama-Elbert S, Lane MA

J Neurotrauma 35(24): 2883-2903– Online [PMID: 29873284] (2018)

“Integration of transplanted neural precursors with the injured spinal cord”

Spruance VM, Zholudeva LV, Hormigo KM, Bezdudnaya T, Marchenko V, Lane MA

J Neurotrauma, 35(15): 1781-1799 [PMID: 29295654] (2018)

“Anatomical recruitment of spinal V2a interneurons into phrenic motor circuitry after high cervical spinal cord injury”

Zholudeva LV, Karliner J, Dougherty K, Lane MA

J Neurotrauma, 34(21):3058-3065 [PMID: 28548606] (2017)

Dr Corcoran has been head of the Neuroscience Drug Discovery Unit since 2008. Our interests are the role of the retinoic acid (RA) signalling pathway in the maintenance and regeneration of the CNS. To date we have two RA drugs in clinical trials. RA acts through the nuclear receptors the retinoic acid receptors (RARs) and retinoid X receptors (RXRs) of which there are three types of each α β and γ. Given that due to their transcriptional action many pathways can be stimulated it suggests that they may have a multifactorial action on signalling cascades in CNS disorders. RA has been shown to induce axonal regeneration following SCI through specific activation of RARβ. Hitherto, RARβ agonists due to poor drug-like properties have only been available as research tools. We have developed C286, an orally available RARβ agonist drug that has multifactorial reparative effects in the CNS. Using three rat models; sensory root avulsion, spinal contusion and spinal nerve ligation, we demonstrate that C286 induces axonal regeneration, modulates neuroinflammation and prevents the onset of neuropathic pain, which are pathologies associated with SCI.
In vivo C286 at doses below the no-observed-adverse-effect level (NOEL) stimulates intrinsic growth programs in the injured neurons and regulates signalling from these to the surrounding glia. This leads to a switch from non-permissive scar tissue to an axonal growth enabling glial network. By bioinformatics we have identified key regulatory pathways that are beneficially modulated by the drug after nerve injury.
The safety and tolerability of C286 are currently being tested in a first in man study (FIM). The drug is demonstrating predictable pharmacokinetics and is well tolerated at proposed therapeutic doses. We have achieved doses required for motor functional recovery based on exposure in the rat and will eventually test the drug at higher exposure levels for sensory recovery.
Biomarkers for efficacy and target engagement are also being tested. We found that both in the rat avulsion model and in humans KCL-286 plasma exposure correlates with RARβ expression in white blood cells (WBCs).
The data taken together suggests that a PIIA trial can be set-up in the near future.

Latest Publications
Goncalves, M. B., Y. Wu, D. Trigo, E. Clarke, T. Malmqvist, J. Grist, C. Hobbs, T. P. Carlstedt and J. P. T. Corcoran (2018). “Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth.” Neurobiol Dis 111: 70-79.

Goncalves, M. B., E. Clarke, C. I. Jarvis, S. Barret Kalindjian, T. Pitcher, J. Grist, C. Hobbs, T. Carlstedt, J. Jack, J. T. Brown, M. Mills, P. Mumford, A. D. Borthwick and J. P. T. Corcoran (2019). “Discovery and lead optimisation of a potent, selective and orally bioavailable RARbeta agonist for the potential treatment of nerve injury.” Bioorg Med Chem Lett 29(8): 995-1000.

Goncalves, M. B., Y. Wu, E. Clarke, J. Grist, C. Hobbs, D. Trigo, J. Jack and J. P. T. Corcoran (2019). “Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells.” J Neurosci 39(16): 3013-3027.

Trigo, D., M. B. Goncalves and J. P. T. Corcoran (2019). “The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor beta signaling.” FASEB J 33(6): 7225-7235.

Goncalves, M. B., J. Moehlin, E. Clarke, J. Grist, C. Hobbs, A. M. Carr, J. Jack, M. A. Mendoza-Parra and J. P. T. Corcoran (2019). “RARbeta Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms.” iScience 20: 554-566.